pentobarbital will decrease the level or outcome of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Solid or moderate CYP3A4 inducers may well increase fee of diazepam elimination; thus, efficacy of diazepam may very well be lowered.
pentobarbital raises toxicity of methoxyflurane by rising metabolism. Contraindicated. Amplified metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will lower the level or result of methylprednisolone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lessen the level or impact of rolapitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Extensive-phrase coadministration of solid CYP3A4 inducers with rolapitant may perhaps substantially lower rolapitant efficacy.
Consistently keep track of critical symptoms in the course of sedation and Restoration time period if coadministered. Diligently titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
pentobarbital will reduce the level or impact of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Pitolisant publicity is lowered by fifty% if coadministered with strong CYP3A4 inducers.
pentobarbital will reduce the level or influence of elbasvir/grazoprevir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic impact of elbasvir/grazoprevir can be decreased if coadministered with sturdy CYP3A inducers and is particularly consequently contraindicated.
pentobarbital will minimize the extent or outcome of parecoxib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Mysterious.
pentobarbital will lower the level or result of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will minimize the level or result of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will lessen the extent or influence of tamoxifen by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep an eye on.
benzhydrocodone/acetaminophen and pentobarbital both equally enhance sedation. Keep away from or read more Use Alternate Drug. Restrict use to clients for whom alternative procedure choices are insufficient
This drug may increase the metabolism of estradiol when administered concurrently; people on oral contraceptives are getting to be pregnant when concurrently addressed with antiepileptic medications; advise an alternate contraceptive process to Girls getting this drug
With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.